Number-one singles[]
| Issue date | Song title | Artist | Sales |
| 7 January | "A Moment Like This" | Leona Lewis | |
| 14 January | "Say It Right" | Nelly Furtado | |
| 21 January | "Shoot Me Down" | Jessica Smith | |
| 28 January | |||
| 4 February | |||
| 11 February | |||
| 18 February | "The Sweet Escape" | Gwen Stefani | |
| 25 February | "What Goes Around... Comes Around" | Justin Timberlake | |
| 4 March | |||
| 11 March | |||
| 18 March | "Glamorous" | Fergie | |
| 25 March | "Girlfriend" | Avril Lavigne | |
| 1 April | |||
| 8 April | "Beautiful Liar" | Beyonce Knowles and Shakira | |
| 15 April | |||
| 22 April | |||
| 29 April | "Shine" | Take That | |
| 6 May | "Give It to Me" | Timbaland feat. Nelly Furtado & Justin Timberlake | |
| 13 May | "Makes Me Wonder" | Maroon 5 | |
| 20 May | "Because of You" | Ne-Yo | |
| 27 May | |||
| 3 June | "Umbrella" | Rihanna featuring Jay-Z | |
| 10 June | |||
| 17 June | |||
| 24 June | |||
| 1 July | |||
| 8 July | |||
| 15 July | "Big Girls Don't Cry" | Fergie | |
| 22 July | "The Way I Are" | Timbaland featuring Keri Hilson | |
| 29 July | |||
| 5 August | "Rehab" | Amy Winehouse | |
| 12 August | "Beautiful Girls" | Sean Kingston | |
| 19 August | "Stronger" | Kanye West | |
| 26 August | |||
| 2 September | "Crank That (Soulja Boy)" | Soulja Boy Tell 'Em | |
| 9 September | |||
| 16 September | |||
| 23 September | "Rockstar" | Nickelback | |
| 30 September | "Who Knew" | Pink | |
| 7 October | |||
| 14 October | "Apologize" | Timbaland featuring OneRepublic | |
| 21 October | "No One" | Alicia Keys | |
| 28 October | |||
| 4 November | "Kiss Kiss" | Chris Brown featuring T-Pain | |
| 11 November | |||
| 18 November | |||
| 25 November | "Breathe Easy" | Jessica Smith | |
| 2 December | |||
| 9 December | "Clumsy" | Fergie | |
| 16 December | "About You Now" | Sugababes | |
| 23 December | |||
| 30 December | "Low" | Flo Rida featuring T-Pain |